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    • 专利摘要:
    The invention is in the field of supplements for animal feed, more particularly in the field of supplements for animal feed to reduce endoparasitic and / or ectoparasitic infestation of animals. The invention provides the use of such a supplement for animal feed in the exploitation of farm animals and poultry. The invention also provides a method of manufacturing such a supplement for animal feed.
    公开号:BE1025705B1
    申请号:E2018/5217
    申请日:2018-03-30
    公开日:2019-06-18
    发明作者:Philippe Dominique Guillaume Planckaert
    申请人:Cosucra Groupe Warcoing Sa；
    IPC主号:
    专利说明:

    IMPROVEMENT OF DISEASE AND GENERAL CONDITIONS OF POULTRY AND CATTLE USING A DRIED CHICORE ROOT
    FIELD OF THE INVENTION
    The invention is in the field of supplements for animal feed, more particularly in the field of supplements for animal feed in order to reduce ectoparasitic infestation of animals. The invention provides the use of such a supplement for animal feed in the exploitation of farm animals and poultry.
    BACKGROUND OF THE INVENTION
    The exploitation of farm animals and poultry often requires animals to live in close proximity to each other, especially in cold environments. This predisposes them to the spread of infections by ectoparasites such as mites, biting insects and the like.
    Since the meat of livestock and poultry is usually intended for human consumption, the regulations regarding the use of pest and disease control agents are very strict to avoid chain contamination food by such agents. Already, farms or barns must be regularly cleaned or rid of ectoparasites in order to avoid poor living conditions for animals and the spread of disease.
    Poultry are, for example, regularly infected with mites, which causes stress, reduced laying performance and higher mortality.
    Farm animals can be subject to parasitic infestations both external and internal by mites, lice, flies, fleas, nematodes such as roundworms, cestodes, or trematodes such as plathelminths (flukes) etc. Scabies, for example in farm animals, is a skin condition caused by microscopic mites in or on the skin. The mites cause intense itching and discomfort which is associated with a decrease in food intake and production. Scratching and rubbing cause significant damage to the skins and fleeces as well as potential wound infections.
    Cattle are regularly infested with mites (mites), especially during winter periods when the animals are in intensive housing and when hygienic conditions are not optimal (the presence of wet ear hairs is favorable for the development of mites).
    The most common species of mites found on livestock are sarcoptes, Chorioptes and Psoroptes ovis. A female mite lays 1 to 3 eggs per day and lives for around 50 days. Mite faeces cause allergic reactions in the host's coat, which reacts with production
    BE2018 / 5217 exudation, thickening of the skin, shards and crusts. Dust mites suck exudates and secretions from the skin. The lesions begin mainly at the attachment of the tail, and around the neck, then spread over the rest of the body. Animals suffer from intense itching and react by scratching, biting and rubbing against objects. Injury causes infections that can lead to weight loss and reduced milk production. About 85% of Belgian BlancBleu cattle are affected by mites, and the disease is also a nuisance for other species in rather humid and cold regions, specifically during winter (Canada, USA, rest of Europe), or for camelids during rainy seasons.
    Galliformes or poultry can also be infested with nematodes such as roundworms or cestodes or trematodes such as plathelminths (flukes), which can in turn be infected with other parasites such as protozoa. Important examples are the Histomonas protozoa such as Histomonas meleagridis causing black head disease in poultry such as chickens and turkeys and occasionally in game birds and pheasants. The parasite is ingested in the eggs of Heterakis gallinarum worms and the infection occurs via the cesspool when the birds are on a contaminated litter. Nematodes attack the cells of the cecum, reach the blood stream, and ultimately infect the liver and kidneys.
    Turkeys are particularly susceptible to this parasite and show signs of depression, poor growth and appetite, sulfur-yellow diarrhea, blood in the faeces (especially chickens) and cyanosis of the head (which refers to black head disease). This disease can represent up to 100% mortality in turkeys and up to 30% mortality in laying hens. The liver of infected birds has severe lesions and a gray color.
    Cryptosporidiosis in calves, leishmaniasis and giardiasis in dogs, toxoplasmosis in cats and protozoa in the rumen of cattle
    Likewise, snails are affected by acariasis as a source of major infection. The preferred habitat of snails are wet conditions. It is also the most favorable environment for acariasis.
    There is no vaccine or treatment for it that would protect livestock by making them immune to mites.
    There is therefore a constant need for new approaches to control pests or ectoparasites on livestock and poultry farms without posing risks to the food chain.
    SUMMARY OF THE INVENTION
    BE2018 / 5217
    Chicory root is known as a prebiotic and has been used as a supplement for animal feed to reduce internal parasitic infestation with nematodes and worms, and to regulate food transit. It must be brought to the credit of the Applicant for having discovered that the dried chicory root can, surprisingly and advantageously, be used to reduce an ectoparasitic and endoparasitic infestation with protozoa in farm animals and poultry.
    To this, the present invention is in particular illustrated by any one or any combination of one or more of the statements listed below:
    1. Composition comprising dried chicory root for use in the reduction, treatment or prevention of an ectoparasitic infestation of farmed animals or poultry or as an insect repellant or for use in the reduction, treatment or the prevention of an infestation of poultry, farm animals or pets with protozoa, in which between 0.1 and 5% of dried chicory root are added to the animal feed, preferably between 0 , 1 and 0.5% for poultry and between 0.5 and 3% for farm animals. Particular examples of ectoparasites are ticks (blood suckers), lice & mites (do not suck blood). Preferred examples of insects on which the composition can have a repelling effect are biting insects (hematophagous, that is to say blood suckers), black flies, horseflies, mosquitoes, fleas, horn flies , midges, mosquitoes, biting stable flies, tsetse flies, etc.
    2. Composition for use according to claim 1, which is administered to poultry, more particularly to laying poultry.
    3. Composition for use according to item 1 or 2, for use in reducing, treating or preventing the presence of red lice in poultry.
    4. Composition according to item 3, which further promotes the reduction of broken eggs, the improvement of the egg-laying cycle, and reduces the mortality of poultry, reduces feather pecking, and reduces or prevents infestation by nematodes or worms.
    5. Composition for use according to claim 1, which is administered to farm animals.
    6. Composition for use according to claim 5, for use in reducing, treating or preventing the presence of a mite infestation in farm animals.
    7. Composition for use according to item 5, for use as an insect repellant in farm animals.
    8. Composition according to any one of claims 1 to 7, comprising inulin, sesquiterpene lactone and a pulp fraction.
    BE2018 / 5217
    9. Composition for use according to any one of items 1 to 8, comprising at least
    50% by weight of inulin, preferably more than 60% by weight of inulin.
    10. A composition for use according to any of claims 1 to 9, wherein said inulin has an average number polymerization degree of at least 3.
    11. Composition for use according to any one of claims 1 to 10, in which the chicory species is Cichorium intybusL ..
    12. Composition for use according to any one of claims 1 to 11, in which said sesquiterpene lactone is chosen from lactucin, dihydrolactucin, lactucopicrin and dihydrolactucopicrin.
    13. A composition for use according to any of claims 1 to 12, wherein said pulp fraction comprises soluble and insoluble fibers.
    14. A composition for use according to any of claims 1 to 13, wherein said pulp fraction comprises cellulose.
    15. Composition for use according to any one of the statements 1 to 14, having a dry matter content of 88% w / w or more, preferably 89% w / w or more, more preferably 90% w / w or more. This corresponds to a moisture content of between about 8 and 12% w / w, preferably between 9 and 11% w / w.
    16. Composition for use according to any one of the statements 1 to 15, consisting essentially of particles having an average diameter of less than 2 mm, preferably ranging from approximately 0.1 to 2 mm, preferably ranging from approximately 0.5 1.5 mm, more preferably about 1 mm.
    17. Composition for use according to any one of items 1 to 16, which consists essentially of a natural product. Indeed, the composition disclosed here has been transformed only by physical means, that is to say by washing with water, drying, grinding, possibly followed by a second stage of drying and fine grinding or fine grinding into small particles of medium particle size as illustrated here. The raw material of chicory root has not been subjected to a chemical treatment with solvents or an extraction medium, etc. in order to obtain the composition of dried chicory root.
    18. Composition for use according to any one of claims 1 to 17, further comprising from 0.5 to 1.5% by weight of calcium stearate in order to further avoid absorption of water resulting in aggregation.
    19. Use of a composition comprising dried chicory root as an additive for animal feed in the production of an animal feed or a supplement for animal feed for the treatment, reduction or prevention of ectoparasitic infestation of farmed or poultry animals or for use in reduction, treatment or prevention
    BE2018 / 5217 of an infestation of poultry, farm animals or pets with protozoa, in which said animal feed product comprises between 0.1 and 5% by weight of said supplement for animal feed based on dried chicory root, preferably between 0.1 and 1% for poultry, between 1 and 5% for pigs, horses or domestic animals and between 0.2 and 1.5% for domestic animals breeding. Particular examples of ectoparasites are ticks (blood suckers), lice & mites (do not suck blood). Preferred examples of insects on which the composition can have a repelling effect are biting insects (hematophagous, that is to say blood suckers), black flies, horseflies, mosquitoes, fleas, horn flies , midges, mosquitoes, biting stable flies, tsetse flies, etc.
    Additionally, said dried chicory composition can also be used to reduce infestation of poultry, farm animals or pets with nematodes such as roundworms or cestodes, or trematodes such as plathelminths (moat), which can in turn be infected by other parasites such as protozoa. Important examples are Histomonas protozoa such as Histomonas meleagridis causing black head disease in poultry such as chickens and turkeys and occasionally in game birds and pheasants. By preventing infestation with nematodes or trematodes, likewise infestation with their protozoan contaminants is avoided or reduced. The chicory root composition also appears to have a purifying effect on the liver of birds infected with protozoa, reducing the pathological symptoms.
    In addition, said dried chicory composition can also be used in order to reduce the infestation of poultry, farm animals or pets with protozoa such as: Histomonaschez protozoa in poultry, cryptosporidiosis in calves, leishmaniasis and giardiasis in dogs, toxoplasmosis in cats and protozoa in the rumen of cattle such as the ciliated protozoa of the ciliated genera Epidinium, Entodinium, Diplodinium, and Holotrich.
    Typically, sheep and cattle should receive a dosage of between 0.2 and 1.5%, preferably between 0.3 and 1% of the composition of dried chicory root mixed in the normal feed.
    Pigs, piglets, horses and dogs or similar domestic animals should typically be given a dosage of between 0.1 and 10% of the composition of dried chicory root mixed in the normal feed. Indicative dosages range from 0.3% to 3%, preferably from about 1 to 1.5% in the feed for sows and piglets and from about 0.3 to 1% in the feed for pigs to fattening for the duration of their stay. Said amount can be increased by up to 5-10% in the last week of fattening of boars to reduce skatole compounds and the boar's sexual odor. In pet food intended for example for cats and
    BE2018 / 5217 dogs, a dosage of between approximately 0.3 and 1.2% of the composition of dried chicory root mixed in the normal food.
    Poultry and birds in general should typically receive a dosage of between 0.1 and 1%, preferably between 0.1 and 0.6% of their normal diet. Indicative dosages are 0.2% in poultry feed, especially during the first 3 weeks of fattening; 0.1 to 0.5% in the feed for laying hens.
    20. Use according to claim 19, in which chicory root is distributed to the animal daily. The period of use can take place during the majority of the reproduction or production period in order to have a protective effect.
    21. Use according to statement 19 or 20, in which chicory root is distributed to the animal daily for a period ranging from approximately 5 to 20 days, more preferably for between 10 and 18 days.
    22. Alternatively, in all of the above statements, the chicory root composition may be replaced by one or more chicory leaves. Such leaves may be provided as a supplement for animal feed for use in reducing, treating or preventing endo infestation with protozoa and / or ectoparasitic of farmed animals or poultry or as an insect repellent . Such leaves can be actively nourished by adding them to the feed or can be sown or planted in the field or pastures of grazing animals, resulting in the distribution of leaves and grass to grazers in the pasture.
    DETAILED DESCRIPTION
    Before describing the present method of the invention, it should be understood that the present invention is not limited to the particular methods, components, products or combinations described, such or such methods, components, products and combinations which can naturally vary. It should also be understood that the terminology used here is not intended to be limiting, since the scope of the present invention will be limited only by the appended claims.
    As used in this text, the singular forms "un", "une", and "le / la" include the referents in the singular as well as in the plural unless the context indicates otherwise.
    The terms "comprising", "comprises" and "constituted by" as used here are synonyms for "comprising", "comprises" or "containing", "contains", and are inclusive or open and do not exclude members , additional elements or steps of method and not cited. It will be appreciated that the terms "comprising", "comprises" and "consisting of" as used herein include the terms "consisting of", "consists" and "consists of", as well as the terms "consisting essentially of", " consists essentially of "and" consists essentially of ".
    BE2018 / 5217
    The quotation of numerical ranges by end points comprises all the numbers and all the fractions subsumed within the respective ranges, as well as the end points cited.
    By the term "approximately" or "approximately" as used herein when referring to a measurable value such as a parameter, quantity, time duration, and the like, is meant to include variations of ± 20% or less, preferably ± 10% or less, more preferably ± 5% or less, and even more preferably ± 1% or less of and from the specified value, to the extent that such variations are appropriate to implement the invention disclosed. It should be understood that the value to which the modifier "approximately" or "approximately" refers is itself also, and preferably, disclosed.
    While the terms "one or more" or "at least one", such as one or more or at least one member (s) of a group of members, are clear in themselves, by further exemplification, the term includes inter alia a reference to any one of said members, or to any two or more among said members, such as, for example,> 3,> 4,> 5,> 6 or> 7 etc. any of said members, and up to all of said members.
    All the references cited in this specification are thus incorporated by reference in their entirety. In particular, the teachings of all the references which are specifically referred to in this text are incorporated by reference.
    Unless defined otherwise, all terms used in the disclosure of the invention, including technical and scientific terms, have the meaning as usually understood by those skilled in the art to which the present invention belongs. As additional information, definitions of terms are included in order to better appreciate the teaching of the present invention.
    In the following passages, various aspects of the invention are defined in more detail. Each aspect thus defined can be combined with any other aspect or any aspects, unless clearly indicated otherwise. In particular, any characteristic indicated as being preferred or advantageous can be combined with any other characteristic or any characteristics indicated as being preferred or advantageous.
    A reference throughout this specification to "one of the embodiments" or "an embodiment" means that a particular feature, structure or characteristic described in the context of the embodiment is included in at least an embodiment of the present invention. Thus, the presence of the expressions "in one embodiment" or "in one embodiment" at various locations throughout this specification do not necessarily refer to the same embodiment, but it is possible. Furthermore, the particular features, structures or features may be combined in any suitable manner, as would be apparent to those skilled in the art from the present disclosure, in one or more modes of
    BE2018 / 5217 realization. Furthermore, while some embodiments described in this text include some, but not others, features included in other embodiments, combinations of features of different embodiments are expected to be within the scope. of the invention, and form different embodiments, as will be understood by those skilled in the art. For example, in the appended claims, any of the claimed embodiments can be used in any combination.
    In the following detailed description of the invention, reference is made to the appended drawings which form part thereof, and in which only illustrative examples of specific embodiments are shown in which the invention can be implemented . It should be understood that other embodiments can be used and that structural or logical changes can be made without departing from the scope of the present invention. The following detailed description, therefore, should not be taken in a limiting sense, and the scope of the present invention is defined by the appended claims.
    By the term "ectoparasites" is meant to include all infesting parasites that live outside the host, either on the skin or on the skin growths of poultry, domestic animals and animals 'breeding. Some nonlimiting examples of bovine ectoparasites are ticks (blood suckers), lice & mites (non blood suckers) such as: Amblyomma ticks, Boophilus cattle ticks, Dermacentor ticks, Haemophysalis ticks, Hyalomma ticks, Ixodes ticks, Rhipicephalus ticks, and cattle mites such as common psoroptes and scabies mites, cattle scabies, Psoroptes, Sarcoptes, Chorioptes, or Demodex causing acariosis or acariasis .
    Some non-limiting examples of poultry ectoparasites are blood-sucking poultry mites, the most important species of which are Dermanyssus gallinae (red louse), Ornithonyssus sylviarum (poultry liponysis), and Ornithonyssus bursa (tropical poultry mite); non-blood-sucking poultry mites, the most relevant species of which are Cnemidocoptes gallinae (depleting scab or scabies scab), Cnemidocoptes mutans (poultry leg sarcopites), Epidermoptes bilobatus (corneal scabies).
    Some nonlimiting examples of ectoparasites of horses and equines in general are Chorioptes equi (scabies of pasterns), Demodex equi (Demodex of horses, leading to demodic scabies), Psoroptes equi (scabies of horses, leading to psoroptic scabies), Sarcoptes scabiei var. equi (common scab, leading to sarcoptic scab).
    Some nonlimiting examples of ectoparasites of sheep and sheep in general are: Chorioptes ovis (chorioptic mange), Psorergates ovis (sarcopte of ovine mange), Psoroptes ovis (mange of sheep), Sarcoptes scabieivar. ovis (sarcoptic mange, or sarcoptic mange).
    BE2018 / 5217
    Some nonlimiting examples of pig ectoparasites are: Demodex phylloides (pig demodex) and Sarcoptes scabieivar. am (swine scabies or sarcoptic scabies).
    Some nonlimiting examples of ectoparasites of cattle and cattle in general are: Demodex bovis (bovine demodex), Chorioptes bovis (chorioptic mange), Psoroptes ovis (bovine mange), Sarcoptes scabieivar. bovis (bovine scabies sarcopt, or sarcoptic mange).
    Some nonlimiting examples of ectoparasites of pets such as cats and dogs are: Demodex canis (demodicosis in dogs), Demodex cati (demodicosis in cats), Otodectes cynotis (ear mites), Notoedres cati (scabies notohedral), Cheyletiellaspp., (cheyletiellosis), Pneumonyssoides caninum (parasite of the nasal cavities), Sarcoptes scabieivar. canis (sarcoptic mange of the dog).
    The term "insect" when used in combination with the use of the dried chicory root composition as an insect repellant is intended to include all biting insects that feed on the blood of farm animals such as horses, equines, cattle including sheep, cattle, camelids, ruminants, pets etc. Some nonlimiting examples of such insects are: biting insects (hematophagous, that is to say blood suckers), black flies, horseflies, mosquitoes, fleas, horn flies, midges, mosquitoes, biting stable flies, tsetse flies, etc.
    The term "endoparasites" is intended to include all internally infested parasites but is particularly intended to include nematodes such as roundworms and cestodes, and trematodes such as plathelminths, as well as protozoan parasites which are transferred via such nematodes and / or trematodes. Important examples are Histomonas protozoa such as Histomonas meleagridis causing black head disease in poultry such as chickens and turkeys and occasionally game birds and pheasants. By preventing infestation with nematodes or trematodes, infestation with their protozoan contaminants is likewise avoided or reduced.
    The term "farm animals" as used herein is intended to include domesticated animals raised in an agricultural environment to produce commodities such as food, fiber, and labor. The term includes mammalian ruminants such as cattle (cattle, bison, buffalo, yaks and the like), sheep (goats, sheep, etc.), pigs, peccaries, camelids, alpacas, deer, elands , elk, moose, donkeys, mules, horses, guinea pigs, rabbits, etc.
    The term "pets" includes small domesticated fur animals such as guinea pigs, guinea pigs, dogs, cats, rabbits, and the like.
    The term "poultry" as used herein includes all domesticated birds raised by humans for, for example, eggs, meat or feathers and includes poultry, more specifically
    BE2018 / 5217 galliforms such as, but not limited to, chicken, duck, goose, quail, emu, peacock, ostrich, pigeon, pheasant, turkey, etc.
    The expression “treatment or prevention”, when used in the context of an ectoparasitic infestation, is intended to encompass any improvement in the condition of the animal, that is to say any reduction in the infestation by ectoparasite, preferably the attenuation of said infestation and the prevention of a reoccurrence of the infestation, thus seriously improving the health and well-being of animals. The prevention of an infestation as a whole is also included in the expression and includes the avoidance of any substantial infestation by ectoparasites in animals which have not been previously infested with them.
    The term "repellant" as used herein refers to characteristics of biting insect repellents and is intended to encompass any reduction in incidents of stings of farm animals or poultry by biting insects, such as indicated in this text. Ideally, no or substantially no incident of insect bites occurs in farm animals or poultry, thereby seriously improving the health and well-being of animals.
    By the term “chicory root” as used herein, is meant the chicory root, in a preferred example, the chicory species is the species Cichorium intybus L. The chicory root comprises two main components, l inulin and pulp. Raw chicory root contains about 20-25% dry matter, which contains 16-17% inulin. When drying to a dry matter content of approximately 90%, this leads to an inulin concentration in the composition of dried chicory root greater than 60%, typically approximately 65%. Said inulin has an average number polymerization degree of at least 3. Additional components of the chicory root composition are sesquiterpene lactones such as those selected from lactucin, dihydrolactucin, lactucopicrin and dihydrolactucopicrin. Typically, at a concentration of about 0.4% by weight. The pulp fraction includes soluble and insoluble fibers and cellulose.
    Likewise, the leaves of the chicory plant may be of interest, since they contain about 0.25% by weight of dry matter of sesquiterpene lactones. The leaves can be fed directly to shearing cattle such as cows, sheep, goats, horses, camelids, etc.
    The dried chicory roots include inulin, sesquiterpenes lactone and a pulp fraction. As used herein, the term "inulin" refers to a mixture of fructose oligo- and / or polysaccharides which may have terminal glucose. Inulins belong to a class of fibers known as fructans. In one embodiment, inulin can be represented, as a function of the terminal carbohydrate motif, by the general formulas GFn and / or Fm, where G represents a unit of glucose, F represents a unit of fructose, n is an integer representing the number of fructose units linked to
    BE2018 / 5217 the terminal glucose unit, and m is an integer representing the number of fructose units linked to each other in the carbohydrate chain, preferably where n is at least 2, and m is at least 2. Inulin for use in the present invention include inulins having terminal glucose which are also referred to as alpha-D-glucopyranosyl- [beta-D-fructofuranosyl] (n-1) -Dfructofuranosides, as well as glucose-free inulins which are also designated by beta-Dfructopyranosyl- [D-fructofuranosyl] (n-1) -D-fructofuranosides. Inulins for use in the present invention may also include branched inulins. Inulins for use in the present invention can also include inulin hydrolysis products such as fructooligosaccharides (FOS), also called oligofructoses, which are fructose oligomers having a DP <20, and they can also include fructooligosaccharides ending with terminal glucose and having a DP of 3-5 synthesized from sucrose. Preferably, said fructooligosaccharides have a number average DP of at least 3 and at most 7. Saccharide chains suitable for inulin of plant origin for use in the invention can have a DP ranging from 2 to about 100 Inulin can be a liquid or a powdery product.
    As used herein, the terms "degree of polymerization" or "(DP)" refer to the number of monosaccharide residues present in an oligo- or polysaccharide. The parameter of average degree of polymerization is also often used. The degree of polymerization is a measure of molecular weight (PM). The DP can be calculated as the ratio of the total PM of the polymer or of the oligomer to the PM of the repeating units.
    The average degree of polymerization (average DP) of a mixture of oligo- or polysaccharides (polydispersed) is the average of the degree of polymerization (DP) of all the molecules present in this mixture of saccharides. The average degree of polymerization here, unless otherwise indicated, is calculated on the basis of the number of molecules for each DP: average DPn or average degree of polymerization in number as described below.
    The determination of the molecular mass distribution of the fructan sample is carried out by High Performance Anion Exchange Chromatography coupled with Pulsed Amperometry Detection (HPAEC-PAD) on a Thermo scientific - Dionex ICS 5000 chromatographic system. the different chain lengths are separated by a Carbopac PA100 4 mm x 250 mm column (+ guard) at 40 ° C with a flow rate of 1 ml / min. 160 mM sodium hydroxide is used as the eluent. A sodium acetate gradient during the analysis makes it possible to separate the various chain lengths. Standards of a mixture of fructan at different concentrations are injected in order to draw the calibration curves and to assign the peaks of the chromatogram on the basis of the retention time of the standards. The calibration curves allow the determination of the concentration of each molecular species in the sample.
    BE2018 / 5217
    From the concentration distribution obtained, the average degree of polymerization in number Dp n is calculated as where Ni is the number of molecules having residues and Dpi the number of residues.
    In one embodiment, the fructan as described here, preferably inulin, has a number average DP of at least 3. In one embodiment, the fructan as described here, preferably inulin, has a Number average PD of at most 500. In one embodiment, said fructan, preferably inulin, has a number average PD of at least 3, for example at least 5, for example at least 7, for example at least 10, for example at least 15, for example at least 20, for example at least 25, for example at least 70. In one embodiment, fructan as described here, preferably inulin, has a number average DP of at least 3 and at most 500, preferably at least 3 and at most 100, more preferably at least 3 and d 'At most 30. In another preferred embodiment, the fructan as described here, preferably inulin, comprises or consists of fructooligosaccharides (FOS). In another preferred embodiment, the fructan as described herein has a number average DP of at least 3 and at most 20, preferably at least 3 and at most 15, such as at least minus 3 and at most 10. In yet another preferred embodiment, the fructan as described herein, preferably inulin, comprises or consists of hydrolyzed or partially hydrolyzed fructan, preferably inulin. Hydrolyzed fructan, such as hydrolyzed inulin, can be obtained for example by the enzymatic route (for example by inulinases) or can, alternatively, be obtained by acid and / or thermal hydrolysis.
    As used herein, the term "sesquiterpene lactones" refers to a class of chemical compounds, called sesquiterpeneoids (formed from three isoprene units) and containing a lactone ring. Sesquiterpene lactones include at least artemisinin, lactucin, deoxylactucin, lactucopicrin, lactucin-15-oxalate, lactucopicrin-15-oxalate.
    As used herein, the term "pulp fraction" refers to the fraction of pulp included in the chicory root. It is mainly composed of soluble and insoluble fibers with a high capacity of water retention.
    For use in the present invention, the chicory root is dried and ground into flakes of between 1 and 10 mm or into a fine powder having an average particle diameter of less than 2 mm, preferably between 0.6 and 1.2 mm , preferably between 0.8 and 1 mm, ranging from 0.1 to 2 mm, ranging from approximately 0.5 to 1.5 mm, more preferably approximately 1 mm. The average particle size can be measured by any known technique such as by sieving with a sieve having known sizes of apertures and will typically be represented by any of D10 (= average
    BE2018 / 5217 arithmetic or number), D32 (= average volume / surface (also called the Sauter average)), or D43 (= the average diameter compared to the volume (also called the DeBroukere average)).
    Alternatively, raw inulin can be used, that is to say the raw inulin juices obtained after the extraction of chicory pulp. This is prepared as follows: raw inulin emerges from the diffusion after separation of the pulp. Raw inulin is practically composed of ± 75% inulin, ± 10% reducing sugars, protein residues (3%) of minerals and sesquiterpene lactones, etc. The concentration of sesquiterpene lactones can therefore be somewhat higher compared to the composition of dried chicory root of the invention, and therefore contains ± 0.6% of sesquiterpene lactones. However, this crude inulin has sticky and hygroscopic properties and is therefore not very convenient for mixing and storage.
    As another alternative, one can use a sesquiterpene lactones concentrate, resulting from the separation of minerals and sesquiterpene lactones from crude inulin. This is prepared as follows: after obtaining the crude inulin, it is also possible to remove the crude juice from the inulin and to obtain a substance having a considerably higher concentration of sesquiterpene lactones. This concentrate can be in the form of a liquid syrup and would be particularly interesting as an ingredient for licking buckets (in the form of mineral blocks having an anti-fly / anti-mosquito and deworming effect).
    As yet another alternative, chicory seeds can be added to pastures, leading to animal feed, etc. in leaves and grass in the pasture.
    Effects
    The composition comprising dried chicory root can be used to reduce, treat or prevent the presence of ectoparasites such as mites, particularly red lice in poultry, scabies in farm animals.
    The effect on reducing infestation with red lice in laying hens can be reasonably extrapolated to birds in general, for example penguins, canaries, parrots, etc.
    The effects obtained by the dried chicory root composition as disclosed here can be extrapolated to other animals than those tested in the disclosure, for example, but not limited to, sheep, goats, pigs and game in general.
    The composition comprising dried chicory root can be used for the control of scabies in farm animals such as horses, sheep and cattle (specifically Belgian Blue-White).
    BE2018 / 5217
    Although the most surprising effect found by the addition of dried chicory root in animal feed was the anti-ectoparasitic and insect repellant effect, many other benefits can be obtained in terms of improving the animal health and welfare.
    The composition comprising dried chicory root can be used to reduce the number of broken eggs and / or increase the egg production cycle in poultry.
    The composition comprising dried chicory root can be used to increase the duration of laying in poultry, even more particularly laying hens.
    The composition comprising dried chicory root can be used to reduce the mortality of poultry, more particularly of laying poultry, even more particularly of laying hens.
    The composition comprising dried chicory root can be used to reduce feather pecking in poultry.
    The composition comprising dried chicory root can be used to treat or prevent malaria.
    The present disclosure is further explained in the examples below, which should not be considered as limiting the scope of protection of the invention.
    EXAMPLES
    Example 1: Effect of the addition of dried chicory root in poultry feed. A comparative test was carried out on a holding of 50,000 laying hens. 0.4% of dried chicory root was added to the existing feed of laying hens. Feeding with this formula was started a month before the end of the production of eggs from laying hens, a period when typically we encounter problems of reducing the quality of the shells, increasing the pecking of feathers etc.
    Quality of the shells
    During the experiment, the number and weight of eggs were recorded daily, food consumption was recorded monthly, and egg production, egg mass, daily food intake and food conversion (food consumed for 1 g of egg mass produced) are calculated as follows: Egg production per day per hen = (average daily egg production average daily number of live birds) x 100.
    At 34, 46, 58 and 70 weeks, an egg from each hen is collected in order to determine the quality indices of the shell, that is to say the thickness of the shell and the density of the shell. The thickness of the shell is measured near the equator of the egg. Shell density (dry shell weight
    BE2018 / 5217 per unit of shell area, mc / cm 2 ) is calculated by Eggware software. The breaking strength of the shell, using an Instron Testing machine, is measured. The eggs are compressed at a constant cross speed of 10 mm / min, and the breaking strength is determined at the time of the shell fracture.
    Mortality rate
    The mortality rate is usually expressed as a percentage, using the following equation: Mortality rate = (number of dead birds total number of birds) x 100
    Measurement of feather pecking
    Moderate feather pecking (GFP) The hens use their beaks to gently peck congeners' feathers. This pecking is generally ignored by the recipient and does not usually lead to the fall of feathers. Usually occurs in periods when the hens will moderate pecking several times in a single period. Usually targeting the back or tail, but may target the head. Count the total number of pecking
    Severe feather picking (SFP) Hens use their beaks to vigorously peck a victim. The victim usually responds to pecking by walking away or fighting back. May cause feathers to fall. Usually occurs during a single event, but can occur twice in a row. Does not occur by periods. Usually targeting the back, rump or tail, but may target the head. Count the total number of pecking
    Aggressive pecking (AP) Occurs when a hen lifts its head and beats another hen energetically with its beak one or more times. Aggressive pecking usually targets the head, but can also target the body. The recipient will usually exhibit avoidance behavior by dodging or moving away from the aggressive fowl. May be associated with chase, confrontation, or jumps. Count the total number of pecking
    Enrichment pecking (EP) Hens use their beaks to peck the top or sides of hay bales or plastic boxes (only in HAY and BOX pieces). Count the total number of pecking
    Measuring red lice
    Since the majority of the mite population is found in the environment rather than on hens, monitoring the number of mites in the chicken coop, on feeders, in nest boxes, cracks, crevices, etc. good measure of the amount of mites present. The number of mites per m2 is measured in the chicken coop before the presence of laying hens and before the cleaning of the chicken coop once the hens are gone. Although. Typically, laying hens stay in the chicken coop for about 18 months.
    Measurement of deworming activity
    BE2018 / 5217
    One way to establish the presence or number of worms is actually to count the worms in the droppings of the hens. Other signs of worm infestation are: dirty behind; ruffled, depressed appearance; weightloss ; fall in egg production; pale crest, etc.
    Results:
    Eggs produced before administration of chicory root in the formula were considered to be of poor quality and the proportion of broken eggs was increasing.
    After 3 to 4 days of inclusion of 0.4% chicory root in the formula, the quality of the shells was significantly improved and the shells were brighter and more colorful. Less egg loss has occurred due to breaking. Likewise, the mortality rate for laying hens, which is usually quite high during this period of the production cycle, has been significantly reduced.
    After 14 days, the inclusion of chicory root in the formula was stopped, and the quality of the shells decreased again in the first following days, clearly linking the effect to the dried chicory root.
    During the 0.4% chicory root inclusion period, feather pecking was also significantly reduced and the feathers started to grow again.
    Unexpectedly, when cleaning the chicken coop after the hens had left, the farmer noticed that he had not been bitten once by mites. In a more detailed study, the bodies of the hens were not infected with red lice. The presence of red lice in the chicken coop was practically zero, which had never been the case before the use of dried chicory root.
    When pullets arrive at the farm building, diarrhea is regularly present due to stress, change of diet, and the risk of fatty liver syndrome (typical of pullets just before laying, by feeding rather excessive). The addition of the dried chicory root composition at 0.4% in the food formula seemed sufficient to improve the quality of the faeces, even only after 2 to 3 days of feeding.
    Example 2 Effect of the Addition of Dried Chicory Root to Horse Feed
    It has been found that tests based on an amount of 75 g / day of dried chicory root composition (approximately 0.5 to 1.5% based on the food) for 10 days were sufficient to have a repellent effect on horseflies. Horses that had a significant number of horsefly bites before treatment were no longer stung after treatment, showing a clear repellent effect.
    In addition, and unexpectedly, the skin of horses treated with dried chicory root healed quickly after the dermatitis caused by bites or infestation by mites. Without wanting to be
    BE2018 / 5217 bound by a theory, the bitter substance in the dried chicory root probably changes the composition of the sweat and / or blood of the animal, and consequently leads to a repellent effect vis-à-vis insects feeding on the blood of horses. Sesquiterpene lactones also have anti-inflammatory and antimicrobial properties, which may partly explain the speed with which healing of wounds and dermatitis is observed.
    EXAMPLE 3 Effect of the Addition of Dried Chicory Root to Cattle Feed
    In order to test the effect in cattle, 150 g of dried chicory root composition were administered to 8 Belgian White-Blue cows which were infested with psoropes and chorioptic mange. After 6 days of application, the first signs of control on infested wounds were identified and no additional growth of the mites occurred.
    When the dosage was reduced to 80 g / day for 1 week, the effect was lost. The re-application of a dosage between 150 and 200 g / day restored control after 5 to 6 days. Said amount corresponds to approximately 1 to 2% of dried chicory root based on the total food.
    Example 4: Effect of the addition of dried chicory root in poultry feed. A comparative test is carried out in a turkey farm, a group where 0.4% of dried chicory root is added to the existing feed and another comparison group receiving the existing feed. The number of nematode infestations and protozoan infestations with Histomonas meleagridis is measured and compared between the two groups.
    Example 5: Effect of dried chicory root on protozoa in general.
    A comparative test is carried out to determine the effect of dried chicory root on the following protozoan infections:
    - cryptosporidiosis in calves
    - leishmaniasis and giardioseche dog
    - toxoplasmosis in cats
    - protozoa in the rumen of cattle such as the ciliated protozoa of the ciliated genera Epidinium, Entodinium, Diplodinium, and Holotrich.
    In each case, one of the animal groups is provided with an existing food to which dried chicory root is added and another comparison group receives the existing food. The number of protozoan infestations is measured and compared between the two groups.
    权利要求:
    Claims (13)
    [1]
    MODIFIED CLAIMS (without annotations)
    1. Composition comprising dried chicory root, preferably from Cichorium intybus L., for use in the reduction, treatment or prevention of an ectoparasitic infestation of farm animals, pets or poultry or as an insect repellant in farm animals or poultry or for use in the reduction, treatment or prevention of an infestation of poultry, farm animals or pets with protozoa, in which 0.1 and 5% by weight of dried chicory root is added to the animal feed, preferably between 0.1 and 1% for poultry, between 1 and 5% for pigs, horses and pets, and between 0.5 and 3% for farm animals.
    [2]
    2. Composition for use according to claim 1, which is administered to poultry, more particularly to laying poultry.
    [3]
    3. Composition for use according to claim 1 or 2, for use in the reduction, treatment or prevention of the presence of red lice in poultry.
    [4]
    4. A composition for use according to claim 1, which is administered to farm animals.
    [5]
    5. Composition for use according to claim 4, for use in reducing, treating or preventing the presence of a mite infestation in farm animals.
    [6]
    6. Composition for use according to claim 4, for use as an insect repellent in farm animals.
    [7]
    7. Composition for use according to any one of claims 1 to 6, comprising:
    at least 50% by weight of inulin, preferably more than 60% by weight of inulin, preferably having an average number polymerization degree of at least 3;
    sesquiterpene lactones, preferably chosen from lactucin, dihydrolactucin, lactucopicrin and dihydrolactucopicrin; and a pulp fraction comprising soluble and insoluble fibers.
    [8]
    8. Composition for use according to any one of claims 1 to 7, having a dry matter content of 88% w / w or more, preferably 89% w / w or more, more preferably 90% w / w or more. This corresponds to a moisture content of between about 8 and 12% w / w, preferably between 9 and 11% w / w.
    [9]
    9. Composition for use according to any one of claims 1 to 8, consisting essentially of particles having an average diameter of less than 2 mm, preferably ranging from approximately 0.1 to 2 mm, preferably ranging from approximately 0.5 1.5 mm, preferably about 1 mm.
    [10]
    10. Composition for use according to any one of claims 1 to 9, which consists essentially of a natural product, optionally further comprising from 0.5 to 1.5% by weight of calcium stearate.
    BE2018 / 5217
    [11]
    11. Use of a composition comprising dried chicory root as an additive for animal feed in the production of an animal feed product or a supplement for animal feed for the treatment, reduction or prevention of an ectoparasitic infestation of farmed animals, pets or poultry or for use in the reduction, treatment or prevention of an infestation of poultry, farmed animals or of pet animals by protozoa, wherein said animal feed product comprises between 0.1 and 5% by weight of said supplement for animal feed based on dried chicory root, preferably between 0.1 and 1% for poultry, between 1 and 5% for pigs, horses or domestic animals and between 0.5 and 3% for farm animals.
    [12]
    12. Use according to claim 11, in which the chicory root is distributed to the animal daily, preferably for a period ranging from approximately 5 to 20 days, more preferably between 10 and 18 days.
    [13]
    13. Chicory leaves for use as a supplement for animal feed for use in reducing, treating or preventing an ectoparasitic infestation of farmed animals or poultry or for use as an insect repellant or for a use in the reduction, treatment or prevention of an infestation of poultry, farm animals or pets with protozoa, in which the said leaves are actively nourished by adding them to the feed or in which chicory plants are sown or planted in the field or pastures of grazing animals, leading to the distribution to the grazers of leaves and grass in the pasture.
    PATENT COOPERATION TREATY
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    同族专利:
    公开号 | 公开日
    CA3073636A1|2019-03-21|
    AU2018333527A1|2020-03-05|
    EP3681524A1|2020-07-22|
    BE1025705A1|2019-06-11|
    WO2019053033A1|2019-03-21|
    US20200383337A1|2020-12-10|
    BR112020004650A2|2020-09-24|
    CL2020000628A1|2020-06-26|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    GB2362574A|2001-01-12|2001-11-28|Angus Erskine Stuart|Essential oil mixture for destruction of poultry red mite & its eggs based on eucalyptus oil, citronellol, terpinen-4-ol & myrica gale|
    WO2016057382A1|2014-10-06|2016-04-14|Blue Prairie Brands LLC|Low bitter chicory products|
    CN112450321A|2020-12-14|2021-03-09|青岛王牌动物健康产品有限公司|Preparation method of insect-expelling soft spindle for plants|
    法律状态:
    2019-07-03| FG| Patent granted|Effective date: 20190618 |
    优先权:
    申请号 | 申请日 | 专利标题
    EP17190677|2017-09-12|
    EP17190677.9|2017-09-12|AU2018333527A| AU2018333527A1|2017-09-12|2018-09-12|Use of dried chicory root to protect poultry and livestock against ectoparasites or as insect repellant|
    US16/641,299| US20200383337A1|2017-09-12|2018-09-12|Use of dried chicory root to protect poultry and livestock against ectoparasites or as insect repellant|
    PCT/EP2018/074538| WO2019053033A1|2017-09-12|2018-09-12|Use of dried chicory root to protect poultry and livestock against ectoparasites or as insect repellant|
    CA3073636A| CA3073636A1|2017-09-12|2018-09-12|Use of dried chicory root to protect poultry and livestock against ectoparasites or as insect repellant|
    BR112020004650-7A| BR112020004650A2|2017-09-12|2018-09-12|use of dried chicory root to protect birds and livestock against ectoparasites or as insect repellent|
    EP18778382.4A| EP3681524A1|2017-09-12|2018-09-12|Use of dried chicory root to protect poultry and livestock against ectoparasites or as insect repellant|
    CL2020000628A| CL2020000628A1|2017-09-12|2020-03-11|Using dried chicory root to protect poultry and livestock against ectoparasites or as an insect repellent.|
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